The Pesticide Program is responsible for regulating the distribution, storage, and use of all pesticides in the state of Nebraska. The goal of the pesticide program in meeting its statutory responsibilities is to protect the citizens of Nebraska and the environment from the harmful effects of pesticides by ensuring these products are handled, stored, and used properly, safely, and effectively. To carry out this goal, the pesticide program has made education and training a priority combined with a vigorous inspection and enforcement program.

The Pesticide Program works in close cooperation with the U.S. Environmental Protection Agency (EPA) in enforcing the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as well as the Nebraska Pesticide Act, in addition to implementing national and regional programs. The Pesticide Program works cooperatively with a number of other state and federal agencies, including the Nebraska Department of Environment and Energy, the University of Nebraska Cooperative Extension Service, the Nebraska Department of Health and Human Services, the Nebraska Natural Resources Districts, and the U.S. Department of Agriculture.